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Unlike the SSRIs mentioned above, dapoxetine was developed specifically for treatment of PE and is the only SSRI approved for treatment of the condition. What sets dapoxetine apart from other SSRIs currently used off-label to treat PE is its pharmacokinetic profile. Briefly, the pharmacology of dapoxetine may be summarized as follows:

  • Dapoxetine is rapidly absorbed following oral administration, whereas other SSRIs take several days or even weeks to reach steady-state concentrations.
  • Peak plasma levels of dapoxetine are reached in approximately 1 hour following a dose of 30 mg or 60 mg
  • Dapoxetine is rapidly eliminated; its initial half-life is approximately 1.4 hours for both doses, compared with 21 hours to 4 days for other SSRIs
  • Dapoxetine has a terminal half-life of 18.7 hours for the 30 mg dose and 21.9 hours for the 60 mg dose
  • Even with multiple dosing, the pharmacokinetics of dapoxetine are unchanged, and it does not appear to accumulate significantly.

These pharmacokinetic characteristics make dapoxetine ideal for on-demand dosing, which reduces the probability of unwanted side effects. Previous Phase II studies identified the optimal dose to be 30 mg initially, with an increase to 60 mg (the maximum recommended dose) if required. Pharmacodynamic studies identified the optimal dose administration time to be 1–3 hours before sexual intercourse.

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PE is highly prevalent and, due to the nature of the disorder, is likely to be under-reported and undertreated. Reported prevalence has also been variable due to the previous lack of an evidence-based definition. In the past, physicians generally considered PE to have a psychological element, hence the historical use of psychotherapy to treat the condition. However, in recent years, the biological component has become more widely understood, and pharmacotherapy is the new focus for the treatment of PE.dapoxetine tablets in Kenya dapoxetine tablets in Nairobi Kenya dapoxetine tablets reviews prosolution pills reviews dapoxetine tablets price dapoxetine tablets vs vigrxplus Tiger King Sex Tablets vs vimaxpills dapoxetine tablets amazon dapoxetine tablets dosage dapoxetine tablets ingredients dapoxetine tablets uk dapoxetine tablets price in Kenya dapoxetine tablets before and after pictures dapoxetine tablets stores dapoxetine tablets where to buy dapoxetine tablets official contacts in Kenya dapoxetine tablets side effects dapoxetine tablets male enhancementmensmaxsuppliments dapoxetine tablets sellers in Nairobi Kenya dapoxetine tablets nairobikenyashop dapoxetine tablets officialcontacts+254723408602 Nairobikenyamombasakisumumalindi Mens max suppliments Nairobi Kenya daresalaam tanzania juba south sudan Khartoum sudan Kigali Rwanda kampala Uganda bunjumbura Burundi kinshasaDRC Maputo Mozambique accra Ghana Dakar Senegal Lusaka Zambia Monrovia angola jibouti asmara Eritrea tunis Tunisia rabat morocco cairo Egypt Harare zimbambwe Mauritius Seychelles Pretoria south Africa lagos Nigeria capeverde eguitorial guinea mogadishu Somalia adisababa Ethiopia togo Liberia sierra dapoxetine tablets seller in africa +254723408602

Two types of PE have been widely recognized, ie, lifelong (primary) and acquired (secondary) PE. Lifelong PE is present from the first sexual experience onwards, occurs in almost all attempts at intercourse, and is considered to have a neurobiological etiology. Secondary PE occurs later in life after a period of perceived normal ejaculatory control, and may have a psychological and neurobiological etiology.

This type of PE may be triggered by stress or linked to adverse events associated with medications. Waldinger et al suggested that, in addition to these well known types of PE, there are two other subtypes, ie, natural variable PE and premature-like ejaculatory dysfunction. Natural variable PE refers to those men reporting occasional early ejaculation in the course of normal events, whilst with the latter, men experience or complain of PE while having normal or prolonged erections.

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The first evidence-based definition of lifelong PE has recently been published by the International Society for Sexual Medicine, and includes the criterion of “ejaculation which always or nearly always occurs prior to or within about 1 minute of vaginal penetration”, ie, an erection of 1 minute or less. Other specified criteria are “… the inability to delay ejaculation on all or nearly all vaginal penetrations, and negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy”.

Prior to this, researchers recruiting patients for clinical studies of PE tended to use the definition given in the DSM-IV-TR, which is similar to that of the International Society for Sexual Medicine, but does not specify an IELT threshold.

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